休息活动计时表现型和心理健康:对基于人口的队列中24小时加速度计的纵向分析
Yanbo Wang1, Lihui Zhou1, Mengjing Zhu1
1School of Public Health, Tianjin Medical University, Tianjin, China.
Health data science
|March 5, 2026
概括
客观地衡量活动时间,就像夜间活动一样,与严重抑郁症 (MDD) 和焦虑症的风险增加有关. 早晨的活动可能会降低MDD风险,与潜在的大脑结构相关.
科学领域:
- 时间生物学和精神病学流行病学.
- 使用客观活动数据进行心理健康研究.
背景情况:
- 基于问卷的时间型评估容易导致报告偏差.
- 24小时加速度计提供休息活动模式的客观测量,作为时间型的代理.
- 本研究调查了客观测量的活动时间和主要抑郁症 (MDD) 和焦虑症的发病率之间的联系.
研究的目的:
- 为了确定加速计衍生活动时间表表现型是否与MDD和焦虑症的发病有关.
- 探索潜在的神经生物学相关性,使用脑部MRI与活动时间和心理健康结果相关.
主要方法:
- 分析了来自94,344名没有先前MDD或焦虑障碍的参与者的英国生物库数据.
- 使用24小时加速度计数据的k-平均集群来分类休息活动定时表型.
- 考克斯比例危险模型评估风险,随后对参与者的子集进行脑部MRI分析.
主要成果:
- 与白天活跃的人相比,夜间活跃的人对MDD (HR 1.30) 和焦虑障碍 (HR 1.27) 的风险明显更高.
- 早晨的活动与MDD风险降低有关 (19%的降低).
- 在深夜/早晨 (00:00-04:59) 进行高体力活动与不良心理健康结果相关,而在早晨 (06:00-08:59) 进行活动则显示出保护作用. 夜间活动与大脑物质量减少有关.
结论:
- 客观测量的活动时间表现型被证明与MDD和焦虑症的发病率有关.
- 探索性MRI发现表明潜在的神经生物学机制将活动时间与心理健康联系起来.
- 需要进一步的研究,包括随机对照试验,以确认修改活动时间是否可以减轻精神障碍风险.
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