幼儿中隐藏的SARS-CoV-2欧米克朗感染:常规检测没有透露什么
Stijn Bogaert1, Hannah Lukasik2, Panagiotis Georgiou3
1Department of Otorhinolaryngology - Head and Neck Surgery, Saint Elisabeth Hospital, Ruhr University Bochum, Bochum, Nordrhein-Westfalen, Germany.
在幼儿中,常规PCR测试COVID-19显示敏感性低,缺失许多感染. 这挑战了目前对无症状儿童的查协议,特别是那些最近从SARS-CoV-2中恢复过来的儿童.
科学领域:
- 儿童传染病 儿童传染病
- 诊断的准确性 诊断的准确性
- 流行病学 流行病学
背景情况:
- 由于COVID-19大流行,需要各种各样的查协议,因不同变异而复杂化,以及在幼儿中具有挑战性的实施.
- 常规的聚合酶连锁反应 (PCR) 测试是主要的查方法,但其在儿科患者中的准确性需要评估.
研究的目的:
- 评估常规PCR测试对幼儿严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 的诊断准确性.
- 为了识别常规PCR遗漏的SARS-CoV-2 Omicron感染,并比较多种测试方式.
主要方法:
- 一项前性队列研究,涉及55名年龄在6岁以下的儿童,接受了腺切除术/桃体切除术.
- 术前PCR与手术内快速抗原测试,单独的鼻/口腔PCR扫描,组织PCR和血清学测试的比较.
主要成果:
- 与组织PCR相比,常规手术前PCR的灵敏度只有20%.
- 术内PCR查达到79%的灵敏度,在所有儿童中检测到51%的SARS-CoV-2,在没有最近感染的儿童中检测到43%的SARS-CoV-2.
- 鼻PCR在检测SARS-CoV-2中表现优于口拭子.
结论:
- 婴儿的常规PCR测试显示敏感性低,假阴性率高.
- 目前对无症状儿童的手术前查方案,特别是那些最近从SARS-CoV-2中康复的儿童,可能需要重新评估,因为可能存在不准确性.
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