洞穴性膜膜瘤:二十年来对自然史,生长动态和治疗反应的回顾性研究
Pedro Cerdeira Ribeiro1, Rui Ramos1, Ana Plácido2
1Department of Neurosurgery, Local Health Unit of Braga, Braga, Portugal.
Surgical neurology international
|March 5, 2026
概括
洞穴鼻膜脑膜瘤通常生长缓慢,支持一些患者的保守管理. 体积测量评估是监测生长的关键,个性化治疗对于管理这些瘤的最佳结果至关重要.
科学领域:
- 神经瘤学神经瘤学
- 神经外科 神经外科
- 放射学 放射学是一门学科.
背景情况:
- 洞穴性膜膜瘤 (CSM) 由于其关键位置而存在治疗挑战.
- 微手术是标准的,但缓慢的生长有利于保守的或放射治疗方法.
- 了解CSM的自然历史和生长对于治疗规划至关重要.
研究的目的:
- 描述CSM的自然历史和生长模式.
- 在20年的时间内评估CSM治疗结果.
- 确定影响CSM管理干预需求的因素.
主要方法:
- 对38名被诊断为CSM的患者 (2004-2024) 的回顾性分析.
- 收集临床,放射和治疗数据.
- 使用MRI测量瘤大小和体积进展;对结果进行统计分析.
主要成果:
- 该队列主要是女性 (81.6%),平均年龄为54.5岁.
- 大多数诊断是症状驱动的 (68.4%),眼是常见的.
- 瘤的体积增长 (0.86厘米3/年) 超过了线性增长 (0.077厘米/年); 63.2%接受了保守的治疗,而36.8%接受了可变控制的积极治疗.
结论:
- 在某些情况下,CSM表现出惰的行为,支持保守的管理.
- 卷度评估优于线性测量,用于监测CSM生长.
- 个性化治疗策略至关重要,需要进一步研究预后标志物.
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