在患有喘的儿童上呼吸道的微生物和代谢分析
Lina Xu1, Qianjun Wan2, Quying Yang1
1Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.
Frontiers in microbiology
|March 5, 2026
概括
儿童喘会改变上呼吸道微生物组和代谢组. L-卡尼丁显示出作为喘评估的生物标志物的潜力,与肺功能相关.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 儿科肺病学 儿科肺病学
背景情况:
- 喘是一种慢性呼吸道疾病,影响着世界各地的儿童.
- 上呼吸道 (URT) 微生物组和代谢组在呼吸系统健康中发挥作用.
- 了解儿科喘中的URT变化对于诊断和管理至关重要.
研究的目的:
- 研究患有喘的儿童URT微生物组和代谢组的特征性变化.
- 探索这些变化与儿科喘患者肺功能之间的关联.
主要方法:
- 招募了患有喘的儿童和年龄相匹配的健康对照.
- 收集了16S rDNA测序 (微生物组) 和LC-MS (代谢学) 的喉拭子.
- 分析了URT微生物群多样性,组成和代谢物概况.
主要成果:
- 在喘组和对照组之间发现了URT微生物群多样性的显著差异.
- 尿路微生物群的丰富性与肺功能指数有负相关性 (预测FVC%,预测FEV1%).
- 已确定L-卡尼丁是潜在的喘生物标志物 (AUC>0.9),其其他代谢物与肺功能相关.
结论:
- 儿童喘与改变的URT微生物组组成和多样性有关.
- 特定的属 (例如,Actinobacillus) 与肺功能参数相关.
- 利卡尼丁 (L-carnitine) 成为儿童喘评估的有前途的生物标志物.
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