根据DXA的骨和身体组成,在早熟青春期的女孩中,早发性thelarche,以及青春期前的对照
Daniela Fava1, Amanda Casirati1, Alessia Angelelli1
1Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.
Journal of the Endocrine Society
|March 5, 2026
概括
中部早熟青春期 (CPP) 和早期青春期 (EP) 的女孩表现出加速的骨积累和身体组成变化. 过早腹痛 (PT) 也会影响这些指标,超重/肥胖是关键因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨生物学 骨生物学 骨生物学
- 身体组成分析 身体成分分析
背景情况:
- 骨矿物质密度 (BMD) 在青春期显著增加.
- 青春期的早期发作,如中部早发性青春期 (CPP),可以改变骨成熟和骨积累.
- 了解这些影响对于长期的骨健康至关重要.
研究的目的:
- 为了评估CPP/早期青春期 (EP) 和早产乳腺炎 (PT) 的女孩的骨和身体组成.
- 将这些结果与青春期前对照 (PC) 进行比较.
主要方法:
- 分析了184名女孩 (5-9岁) 怀疑CPP/EP (n=108),PT (n=76) 和47名PC.
- 双能X射线吸收计 (DXA) 评估了骨矿物质密度 (BMD),骨矿物质含量 (BMC) 和身体成分.
- 衍生措施包括骨矿物质表面密度 (BMAD),骨骨分数 (TBS) 和脂肪分布比率.
主要成果:
- 与对照组相比,患有CPP/EP的女孩的身高,BMI,骨龄,脂肪质量,肌肉质量和无脂肪质量指数 (FFMI) 较高.
- CPP/EP组的L1-L4 BMD显著更高;观察到BMD变化 (ΔBMD) 的趋势更高.
- 过早的thelarche (PT) 与较高的Android-gynoid脂肪比率 (A/G) 和TBS相关. 在PT中超重/肥胖和 pubarche发作与L1-L4 BMAD Z-score增加相关.
结论:
- 与对照组相比,CPP/EP和PT组都显示脂肪和瘦肉量增加.
- PT的特征是较大的中心脂肪度.
- 在早期青春期发育的女孩中,DXA对评估身体组成和骨积累有价值.
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