在患有HPV感染的年轻男性中,高风险的人类乳头瘤病毒感染与9-valent疫苗类型的持续感染
Cara J Broshkevitch1, Joseph E Tota1, Joel M Palefsky2
1Department of Epidemiology, Biostatistics and Research Decision Sciences, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, USA.
Open forum infectious diseases
|March 5, 2026
概括
流行的人类乳头瘤病毒 (HPV) 感染增加了异性恋男性持续性HPV感染的风险,但不是与男性发生性关系的男性. 建议所有男性接种HPV疫苗.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 人类乳头瘤病毒 (HPV) 是一种常见的感染,具有长期健康影响.
- 关于流行HPV感染与不同男性群体发生持续感染的风险之间的关联,数据有限.
- 了解这些关联对于制定有效的预防策略至关重要.
研究的目的:
- 评估流行9-价值HPV (9vHPV) 感染与异性恋男性 (HM) 和与男性发生性关系的男性 (MSM) 发生性持续性9vHPV感染的风险之间的关联.
- 为公众健康推男性HPV疫苗接种提供信息.
主要方法:
- 分析了一项跨国4价值HPV疫苗试验的安慰剂臂队列,包括1459名HM和260名16-27岁的MSM.
- 持续发生的感染被定义为在至少两次连续访问中检测到的新型9vHPV类型的阴道部位.
- 统计分析包括发病率差异 (IRD) 和调整后的发病率比率 (IRR).
主要成果:
- 发生性持续性9vHPV感染的发病率在患有流行感染的HM中为每100人/年10.18,而在没有感染的人群中为5.94.
- 在HM中,流行的9vHPV感染与发生性持续性感染 (调整后的IRR) 风险增加1.52倍相关.
- 在MSM中,无论基线HPV状况如何,发生性持续感染的风险很高 (11.74/100人年).
结论:
- 患有HPV感染的异性恋男性患有持续感染的风险更高.
- 发生性持续性HPV感染的风险在与男性发生性关系的男性中很高,不管基线感染状况如何.
- 这些发现强调了所有男性接种HPV疫苗的重要性,以预防持久性感染.
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