尼泊尔第三级护理儿童医院输血依赖的thalassemia患者的临床流行病学概况:一项观察性研究
Bishow Nath Adhikari1, Sudhir Sapkota1, Sani Sipai1,2
1Department of Pediatrics, Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal.
JNMA; journal of the Nepal Medical Association
|March 5, 2026
概括
尼泊尔的输血依赖性thalassemia不成比例地影响男性,其中β-thalassemia主要是最常见的. 超过一半的儿科患者经历过多的铁负荷和并发症,突出需要改善后续和化遵守.
科学领域:
- 血液学 血液学 血液学
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 输血依赖性沙拉西米亚在尼泊尔是一个重大的公共卫生挑战.
- 有限的国家数据和获得综合护理的机会加剧了这个问题.
- 了解临床-流行病学特征对于有针对性的干预至关重要.
研究的目的:
- 调查儿科输血依赖性沙拉西米亚患者的临床和流行病学特征.
- 评估当前的管理实践,包括输血和化.
- 为了确定这个患者队列中常见的并发症和营养状况.
主要方法:
- 尼泊尔坎蒂儿童医院的回顾性观察研究.尼泊尔.
- 包括15岁以下的输血依赖性沙拉西米亚病例 (2020年1月至2024年12月).
- 从医院记录收集关于人口统计,临床特征,管理和并发症的数据;描述性统计分析.
主要成果:
- 确定了187名儿科患者,64.71%是男性,83.42%患有β-thalassemia major.
- 诊断时的中位数年龄:10个月;输血前平均血红蛋白:8.86g/dL.
- 并发症的高患病率:内分泌病变 (55.62%),肝功能障碍 (34.76%) 和铁过载 (血清费里丁在49.19%中>2500 ng/mL).
结论:
- 主要的Beta-thalassemia是主要的形式,观察到男性占主导地位.
- 超过一半的患者患有铁过载和相关并发症.
- 加强定期的随访和改善对化疗法的遵守对于更好的患者结果至关重要.
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