抗精神病药物降低了药物先验早期精神病炎症的外围标志物:试点研究
Nicole Šafářová1,2,3, Marián Kolenič1,2, Ivana Tašková3,4
1Early Episodes of SMI Research Center, National Institute of Mental Health, Klecany, Czechia.
Frontiers in psychiatry
|March 5, 2026
概括
在第一发精神病 (FEP) 患者的抗精神病治疗显著降低了周围炎症标志物,包括中性粒细胞/淋巴细胞比率 (NLR),单细胞/淋巴细胞比率 (MLR),血小板/淋巴细胞比率 (PLR) 和全身免疫炎症指数 (SII). 这表明早期抗精神病治疗的剂量依赖的抗炎作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 神经炎症是精神分裂症病理生理学的关键因素.
- 外围炎症标志物可以间接评估神经炎症.
- 在第一次精神病发作 (FEP) 中,早期干预至关重要.
研究的目的:
- 研究抗精神病治疗对未服用过抗精神病药物的FEP患者周围炎症标志物的影响.
- 探索抗精神病药物对炎症的剂量依赖作用.
主要方法:
- 试点研究涉及33名未经药物治疗的FEP患者.
- 在入院 (V0) 和随访 (V1) 时采集的血液样本.
- 计算的中性细胞/淋巴细胞比率 (NLR),单细胞/淋巴细胞比率 (MLR),血小板/淋巴细胞比率 (PLR) 和全身免疫-炎症指数 (SII).
- 测量的累积抗精神病药物暴露量以原胺等效剂 (cCPZ) 表示.
主要成果:
- 累积抗精神病药物暴露显著预测了 ΔNLR, ΔMLR, ΔPLR 和 ΔSII 的减少.
- 在错误发现率调整后,关联仍然很重要.
- p值在0.028到0.048之间,表明了统计学意义.
结论:
- 在FEP中早期的抗精神病治疗表明了持续的剂量依赖的抗炎作用.
- 研究结果表明,抗炎机制在抗精神病作用中可能发挥作用.
- 需要进行更大规模的研究来证实这些探索性发现.
相关概念视频
Psychosis and Antipsychotic Drugs: Overview
1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Psychosis: Goals of Pharmacotherapy
645
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
645
Drug Therapy
346
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
346
Antipsychotic Drugs: Typical and Atypical Agents
1.1K
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.1K
Antipsychotic Drugs: Therapeutic Uses and Side Effects
1.0K
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
1.0K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
2.3K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.3K


