代谢特征连接和调解心血管疾病患者的久坐时间驱动的死亡风险
Min Zhu1,2, Keke Ding1, Peiyang Luo1
1Center for Translational Medicine, Shanghai Sixth People's Hospital, Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in sports and active living
|March 5, 2026
概括
久坐不动的行为增加了心血管疾病 (CVD) 的死亡风险. 代谢途径,包括脂肪酸和氨基酸代谢,调解这种风险,为个性化心血管疾病管理提供目标.
科学领域:
- 心血管科学 心血管科学
- 代谢学 代谢学 代谢学
- 流行病学 流行病学
背景情况:
- 久坐不动的行为与心血管疾病 (CVD) 有关,但潜在的分子机制,特别是代谢途径,尚未完全理解.
- 澄清这些联系对于开发有针对性的干预措施来减轻与不活动相关的CVD风险至关重要.
研究的目的:
- 调查代谢组在静坐行为和心血管疾病患者全因死亡率之间的关联中扮演的调解角色.
- 为改善心血管疾病管理策略提供新的代谢见解.
主要方法:
- 利用了来自13561名心血管疾病参与者的英国生物库数据 (2006-2010年),分析了249个血清代谢物和久坐时间.
- 采用Cox比例危险和弹性网络回归模型来识别与久坐行为和死亡风险相关的代谢特征.
- 进行了调解分析,以量化特定代谢物在静坐行为与死亡率的联系中的作用,并使用后续数据进行了验证.
主要成果:
- 确定了与久坐行为相关的35种代谢物;其中24种也与增加全因死亡风险有关.
- 静坐时间 (HR 1.08) 和综合代谢特征 (HR 1.16) 独立预测了更高的死亡率.
- 关键的介导代谢物包括脂肪酸代谢,分支链氨基酸代谢和与炎症相关的葡萄糖蛋白.
结论:
- 揭示了重要的代谢途径,调解了心血管疾病患者的久坐行为和死亡率之间的联系.
- 突出了特定的代谢物 (例如,糖蛋白乙,脂质比率) 作为个性化干预措施降低心血管疾病死亡率的潜在目标.
- 研究结果强调了考虑代谢概况在控制心血管健康中与久坐行为相关的风险方面的重要性.
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