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在炎症性肠病中残疾的发生率:系统性审查和元分析
Olga Maria Nardone1, Giulio Calabrese2, Alexander C Ford3,4
1Department of Public Health, University of Naples Federico II, Naples, Italy.
Inflammatory bowel diseases
|March 5, 2026
概括
近三分之一的炎症性肠病 (IBD) 患者患有中度至重度残疾. 这种患病率在克罗恩病和活跃疾病中更高,突出显示了对一致评估的需要.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 关于残疾人的研究.
背景情况:
- 炎症性肠病 (IBD) 包含身体,心理和社会限制.
- 文化和医疗保健因素的全球变化影响IBD的残疾患病率.
研究的目的:
- 系统地审查和元分析IBD患者中度至重度残疾的综合患病率.
- 调查IBD类型,疾病活动,地理位置和评估工具对残疾患病率的影响.
主要方法:
- 在MEDLINE,Embase和Embase Classic的系统文献搜索到2025年3月1日.
- 包括横截面,队列,基于注册表和病例控制的研究.
- 专注于研究报告中度至重度残疾使用IBD盘或IBD-残疾指数在成人IBD患者.
主要成果:
- 在17个国家的7897名IBD患者中,中度至重度残疾的综合患病率为29.6%.
- 在活跃的IBD (56.9%) 与不活跃的疾病 (27.0%) 中观察到更高的残疾率.
- 克罗恩氏病患者 (36.9%) 的残疾程度高于性结肠炎患者 (30.8%). 疾病活动增加了超过三倍的残疾几率.
结论:
- 中度至重度的残疾影响了近三分之一的IBD患者,克罗恩病和活跃疾病的发病率更高.
- 即使在IBD缓解期间,残疾仍然存在,这凸显了持续评估的必要性.
- 这些发现突显了IBD中残疾的重大负担,并为临床实践提供了信息.
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