基于生物聚合物的漂浮药物输送系统的进步,用于胃治疗治疗
Adarsha Bachhar1, Shila Barman2, Arindam Sarkar1
1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
Journal of biomaterials science. Polymer edition
|March 5, 2026
概括
漂浮式药物递送系统 (FRDDS) 是通过延长胃内停留时间来改善口服药物吸收的有希望的解决方案. 这种方法提高了药物的有效性,并减少了各种疾病的剂量频率.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 胃肠病学 胃肠病学
背景情况:
- 有效的胃药物吸收对于具有pH依赖溶解度或狭窄吸收窗口的药物来说具有挑战性.
- 传统的剂量形式由于胃快速排空而导致生物可用性较差和胃肠道过路变化.
- 由于配方的复杂性和不一致的胃保留,现有的胃系统在临床上取得了有限的成功.
研究的目的:
- 批判性地评估浮式飞药物输送系统 (FRDDS) 对于胃保持的最新进展.
- 探索FRDDS的形成机制,性能和临床适用性.
- 确定翻译FRDDS技术的挑战和机遇,以改善口服药物治疗.
主要方法:
- 关于FRDDS的最新科学文献的审查.
- 对FRDDS机制的分析,包括木形成和浮力.
- 评估配方策略及其对食疗效果的影响.
- 讨论临床适用性和翻译挑战.
主要成果:
- FRDDS形成低密度浮力凝结构,可显著延长胃内存时间.
- 在胃中持续存在的药物增加了在酸性条件下溶解,并使特定部位的释放.
- FRDDS提高治疗效率,并允许减少剂量频率.
- 关键的挑战包括胃环境的个体间变异性,食禁食效应和转化限制.
结论:
- FRDDS代表了一个强大的,多功能平台,用于胃食药物输送.
- 这项技术具有显著的潜力,可以增强慢性,传染性和胃相关疾病的口服药物治疗.
- 需要进一步研究可变性和翻译问题,才能充分实现FRDDS的临床益处.
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