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Updated: Mar 6, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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通过双链RNA结合蛋白DGCR8控制干扰素反应的逆转移素驱动激活

Ana Gázquez-Gutiérrez1,2, Priscilla Chin3, Guillermo Peris2,4

  • 1Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada 18071, Spain.

Nucleic acids research
|March 5, 2026
PubMed
概括

双链RNA结合蛋白DGCR8通常通过控制可转移元素的内源dRNA来防止免疫过度激活. 它的失活会触发有害的I型干扰素反应,与22q11.2删除综合征相关.

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