患有原发性硬化胆管炎的患者的心血管风险概况
J A M Sleutjes1, N van de Pol1, A J van der Meer1
1Department of Gastroenterology and Hepatology.
European journal of gastroenterology & hepatology
|March 5, 2026
概括
原发性硬化性胆管炎 (PSC) 患者,特别是炎症性肠病 (IBD) 患者,通常心血管健康不佳. 由于可修改的风险因素,许多人经历了动脉样硬化心血管疾病 (ASCVD) 事件,这表明需要主动管理.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 原发性硬化性胆管炎 (PSC) 中的慢性炎症与动脉样硬化增加有关.
- 在PSC患者中评估心血管疾病 (ASCVD) 风险和心血管健康 (CVH) 是至关重要的.
研究的目的:
- 评估原发性硬化性胆道炎 (PSC) 患者的动脉样硬化性心血管疾病 (ASCVD) 风险和心血管健康 (CVH).
- 为了比较PSC患者与没有炎症性肠病 (IBD) 之间的这些个人资料.
主要方法:
- 98名PSC患者 (65%患有IBD) 的横截面研究.
- 评估包括人体测量,血清样本,问卷和医疗记录.
- 心血管健康 (CVH) 评分是使用美国心脏协会指南计算的.
主要成果:
- 在PSC-IBD患者中,肥胖,高血压和代谢综合征的发病率较高.
- 非理想的心血管健康 (CVH) 在PSC-IBD患者中更为普遍 (46%对22%).
- 10%的PSC患者先前有ASCVD事件,通常与可修改的风险因素有关.
结论:
- 相当一部分PSC患者,特别是IBD患者,心血管健康状况不理想 (CVH).
- 在这个队列中,大多数ASCVD事件与可修改的风险因素有关.
- 建议对PSC患者进行积极的ASCVD监测和风险管理.
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