局部特异的人体内源性逆转录病毒ERVK18表达表明炎症的微环境和在小细胞肺癌中有利的免疫治疗结果
Xingyuan Wu1, Kunkun Sun2, Jingwei Zhang1
1Peking University People's Hospital Beijing China.
概括
人体内源逆转录病毒K (HERV-K) 转录ERVK18显示出作为小细胞肺癌 (SCLC) 免疫治疗的生物标志物具有前途. 高ERVK18表达与炎症瘤微环境和更好的患者结果相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 免疫疗法已经推进了小细胞肺癌 (SCLC) 治疗,但预测生物标志物很少.
- 人体内源逆转录病毒-K (HERV-K) 影响各种癌症的免疫反应,但其在SCLC中的作用尚不清楚.
- 了解HERV-K与SCLC的免疫微环境和免疫疗法反应的关联至关重要.
研究的目的:
- 研究HERV-K转录在SCLC免疫治疗中的预后和预测价值.
- 探索HERV-K表达,瘤免疫微环境和SCLC患者的临床结果之间的关系.
主要方法:
- 在SCLC队列 (IMpower133,PKUPH) 中使用TELESCOPE分析了局部特定的HERV-K表达.
- 免疫组织化学和RNA-FISH验证了HERV-K转录表达.
- 单细胞RNA测序和多重免疫组织化学特征瘤免疫微环境.
主要成果:
- 虽然HERV-K作为一个整体缺乏预后价值,但ERVK18转录与改善的SCLC免疫治疗结果相关.
- 高ERVK18表达与免疫相关的特征,增加免疫细胞透和增强的T细胞细胞毒性有关.
- 在IMpower133队列中,ERVK18预测了接受阿特佐利祖马布加化疗与单独化疗的患者的更好的生存率.
结论:
- 升高的ERVK18表达意味着SCLC中的炎症瘤微环境.
- 在SCLC中,ERVK18作为一线免疫治疗反应的双重预后和预测生物标志物.
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.5K
Non-LTR Retrotransposons
13.6K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.6K
Mechanisms of Retrovirus-induced Cancers
7.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.1K
LTR Retrotransposons
20.0K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
20.0K
Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K


