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急性后部多焦点斑块性色素上皮质病变谱在多模式成像:一个严重性驱动的缺血连续体

Luca De Simone¹, Riccardo Genovese^2,3, Vincenzo Carmina⁴

¹Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Ocular immunology and inflammation

|March 5, 2026

概括

多模式成像揭示了急性后部多焦点斑块性色素表皮病变性 (APMPPE) 的频谱,确定了外围变体 (PAPMPPE) 作为经典APMPPE和大发性胆管炎 (AC) 之间的中间表型. 这支持疾病严重程度的连续性.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
视网膜疾病视网膜疾病

背景情况:

急性后部多焦点斑块性色素表皮病 (APMPPE) 是一种罕见的炎症状况,影响视网膜.
了解APMPPE的频谱和成像特征对于诊断和管理至关重要.
之前的研究已经描述了经典的APMPPE和雄原性胆管炎 (AC),但这些实体之间的关系仍在争论中.

研究的目的:

在APMPPE频谱中定义多式成像模式.
将成像特征与APMPPE和相关疾病的潜在病变发生相关联.
调查疾病呈现连续性的可能性.

主要方法:

对患有APMPPE谱系疾病的患者进行了回顾性,观察性,单中心研究.
将其分为三种模式:经典的APMPPE,外围的APMPPE和大发性胆管炎 (AC).
多式成像包括彩色 fundus 摄影 (CFP), fundus 自流光 (FAF) 和氨酸绿色血管学 (ICGA).

主要成果:

分析了10名患者的19只眼睛,分为经典APMPPE (3只眼睛),外围APMPPE (8只眼睛) 和AC (8只眼睛).
在9/19眼中观察到一个超光的外周血管邻晚期ICGA上的斑块.
在所有AC眼中都存在远端外围FAF低自光,在经典APMPPE和外围APMPPE中缺席,表明不同的模式.

结论:

通过使用多式成像,确定了一个独特的表型模式,外围APMPPE (PAPMPPE).
PAPMPPE表现出经典的APMPPE和AC之间的中间表型.
这些发现支持在APMPPE频谱内的严重程度分级连续的概念.

关键词:

在APMPPEPPE上急性后部多焦点斑块性色素上皮质变形症强烈的冠状腺炎.冠状毛囊炎 (choriocapillaritis) 是一种表皮炎.多模式成像技术多模式成像技术

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