与代谢功能障碍相关的脂肪肝疾病和膝关节骨关节炎风险:一项前性队列研究
Yongchun Zhang1, Lina Jiang2, Xiaowen Teng1
1Department of Orthopedics, The Affiliated Qingdao Third People's Hospital of Qingdao University, Qingdao, China.
Clinical and experimental medicine
|March 5, 2026
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与膝关节骨关节炎 (KOA) 的风险增加有关. 炎症部分解释了这种关联,突出了MAFLD.
科学领域:
- 代谢和肌肉骨健康
- 肝脏和炎症疾病 肝脏和炎症疾病
背景情况:
- 膝关节关节炎 (KOA) 是慢性疼痛和残疾的主要原因.
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一种系统性代谢障碍,影响各种器官.
- 关于MAFLD-KOA关系的前性数据有限,尽管有横截面证据.
研究的目的:
- 调查MAFLD和事件KOA之间的纵向关联.
- 评估炎症,特别是高灵敏性C反应蛋白 (hs-CRP) 在这种关系中的调解作用.
主要方法:
- 利用了303,604名没有基线骨关节炎的参与者的英国生物库数据.
- 使用脂肪肝指数和代谢标准定义MAFLD;评估纤维化与纤维化-4分数.
- 采用Cox比例危险回归和调解分析,平均随访时间为13.67年.
主要成果:
- MAFLD与18%的KOA风险增加有关 (HR1.18,95%CI1.13-1.24),风险随着纤维化的严重程度而升级.
- 超重/肥胖MAFLD亚型显示出一个显著的KOA关联 (HR 1.19,95% CI 1.14-1.25).
- hs-CRP部分调解了8.94%的MAFLD-KOA相关性.
结论:
- MAFLD独立地与患膝关节关节炎的风险更高有关.
- 炎症在MAFLD和KOA之间的联系中发挥着部分调解作用.
- 这些发现支持MAFLD作为影响肌肉骨健康的全身性疾病,需要综合管理.
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