美国老年人中抗胆固醇负担和相关死亡率的32年趋势:基于人口的研究
Kai Wei1, Shuimei Sun1, Chun Chen1
1Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Age and ageing
|March 5, 2026
概括
30年来,老年人的抗胆固醇负担 (AB) 已经下降,但高暴露仍然显著增加死亡风险. 针对更安全的处方和解除处方的持续努力对于老年护理至关重要.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 抗胆固醇负担 (AB) 与老年人的不良健康结果和死亡率有关.
- 与AB相关的国家趋势和长期死亡风险需要进一步定义.
研究的目的:
- 分析32年来美国老年人抗胆固醇负担 (AB) 的国家趋势.
- 调查高血清和全因,心血管和癌症死亡率之间的长期关联.
主要方法:
- 从1988-94年至2017年至2020年3月的全国健康和营养检查调查 (NHANES) 中利用了来自16188名老年人的数据.
- 评估AB使用2023年美国老年病学协会酒标准®和四个验证的尺度 (ARS,ADS,ACB,ACSBC).
- 通过使用考克斯比例危险模型与国家死亡指数的联系来检查死亡结果.
主要成果:
- 强抗胆固醇药物使用率和高AB (分数≥3) 的流行率在所有尺度上显著下降 (pTrend < .05).
- 高血压独立地与所有原因死亡率 (例如,ADS:HR 1.65) 的升高,心血管死亡率 (例如,ADS:HR 1.94) 和癌症死亡率 (例如,ADS:HR 1.40) 相关.
- 这些关联在综合共变量调整后仍然显著.
结论:
- 尽管患病率有所下降,但高抗胆固醇负担 (AB) 仍然是美国老年人死亡率的重要预测因素.
- 调查结果强调,在老年护理中继续需要更安全的处方实践和减少处方的举措.
- 需要持续的干预措施来缓解与抗胆固醇药物在老年人群中相关的长期健康风险.
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