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双边艾尔斯病通过玻璃切除术和抗VEGF疗法治愈:一个病例报告

Zuzanna Lelek¹, Martyna Machaj¹, Katarzyna Krysik^1,2

¹Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, Sosnowiec, Poland.

The American journal of case reports

|March 5, 2026

概括

本案例研究表明,早期玻璃切除术与免疫抑制和抗VEGF治疗相结合,可以显著改善Eales患者的视力.

科学领域:

眼科医生眼科眼科
视网膜血管炎视网膜血管炎
免疫学免疫学免疫学

背景情况:

伊尔斯病是一种罕见的异常性视网膜血管炎,影响年轻成年男性.
它的特征是周围炎,视网膜缺血和新血管化,往往导致玻璃体出血和拉力视网膜脱落.
及时诊断和个性化管理对于保持视力至关重要.

研究的目的:

描述双边艾尔斯病的复杂病例,其临床过程不对称.
为了说明一种治疗策略,包括玻璃切除术,全身免疫抑制和抗VEGF疗法.
突出双通道抑制在管理复杂视网膜血管炎中的作用.

主要方法:

一名32岁的男性被诊断患有双边艾尔斯病,接受了量身定制的治疗方法.
最初的治疗包括左眼视切除术,白内障提取,泛视网膜光凝 (PRP) 和全身免疫抑制 (阿扎西奥普林,甲铁).
随后右眼的进展需要进一步干预,静脉注射甲基前素,PRP,静脉内法里西马布和玻璃切除术.

主要成果:

在最后的随访中,患者在两只眼睛都获得了良好的视力敏度 (BCVA 0.00 logMAR).
法里西马布抑制了VEGF-A和血管蛋白-2 (Ang-2),有助于血管稳定.
不对称的疾病过程需要个性化和多方面的治疗策略.

结论:

早期的玻璃切除术,全身免疫抑制和抗VEGF疗法可以在双边艾尔斯病中带来有利的长期视觉结果.
法里西马布对VEGF-A和Ang-2通路的双重抑制在复杂的视网膜血管炎管理中显示出前景.
需要进一步的研究来确定各种抗VEGF药物的有效性,以治疗这种罕见的疾病.

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