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Updated: Mar 7, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
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通过增加PolΘ蛋白的表达,HPV16 E6蛋白促进微同质介导的病毒融合

Guangli Zhu1,2, Shuhei Asada1, Jithma P Abeykoon3

  • 1Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.

Proceedings of the National Academy of Sciences of the United States of America
|March 5, 2026
PubMed
概括

HPV16 E6 型蛋白通过稳定 DNA 聚合酶 teta (PolΘ) 来促进微同质介导的末端结合 (MMEJ) DNA 修复. 这一过程涉及E3结合酶UBE3A和RAD23A,促进病毒基因组集成和癌症的发展.

关键词:
基因聚合酶甲基 (PolΘ) 的基因.E6 是一种上蛋白质.人类乳头瘤病毒16微同质介导的末端连接 (MMEJ)病毒基因组整合病毒基因组整合

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