布拉迪基宁的重复融合进化模仿作为防御毒素
Naiqi Shi1, Axel Touchard2, Vanessa Schendel1
1Institute for Molecular Bioscience, University of Queensland, QLD, Australia.
概括
融合进化导致黄蜂和青中类似的布拉迪基宁 (BK) 类. 这些防御分子独立地从毒素进化,由捕食者受体选择驱动,而不是共同的祖先.
科学领域:
- 进化生物学 进化生物学
- 分子进化分子进化
- 生物化学 生物化学
背景情况:
- 融合进化导致与无关的物种具有相似的特征.
- 类似于布拉迪基宁 (BK) 的可以在女鸟的毒液和鸟的皮肤分泌物中找到.
- 这些BK类的进化起源以前不清楚.
研究的目的:
- 为了研究黄蜂和青中BK类的进化起源.
- 为了确定这些是否与脊椎动物布拉迪基宁共享共同的祖先.
- 了解自然选择在塑造这些分子中的作用.
主要方法:
- 对代码基因的遗传学分析.
- 进行比较基因组学以追踪基因起源.
- 功能性测试以评估受体结合和疗效.
主要成果:
- 像BK的基因在海门和anuran没有与脊椎动物的BK基因共享祖先.
- 这些从祖先的毒素基因中独立地多次进化.
- 与BK的相似性是由在捕食者受体上有效性的选择驱动的.
结论:
- 自然选择推动了远距离相关的血统中重复融合的分子进化.
- 毒素和分泌物中的BCK类类化合物在进化过程中趋同,以防御捕食者.
- 这项研究说明了功能约束如何导致类似的分子解决方案.
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