自杀死亡率增加与胰腺炎之间的关联:一项全国性队列研究
Kwang Hyun Chung1, In Rae Cho2, Dong Kee Jang3
1Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Yongsan-gu, Seoul 04401, Republic of Korea.
患有慢性胰腺炎的个人有明显更高的自杀死亡风险. 没有进展为慢性疾病的急性胰腺炎没有显示出明显增加的自杀风险,突出了针对性护理的需要.
科学领域:
- 胃肠病学和精神病学 在
- 公共卫生和流行病学
背景情况:
- 胰腺炎是与发病率相关的重大健康问题.
- 有限的基于人口的数据存在于胰腺炎和自杀风险之间的联系.
研究的目的:
- 调查胰腺炎和自杀死亡之间的关联在一个大规模的全国性队列中.
- 为了区分与急性和慢性胰腺炎相关的自杀风险.
主要方法:
- 分析了一组全国范围的2,732,294名40岁以上的成年人.
- 参与者根据胰腺炎病史 (急性或慢性) 分类,并对自杀死亡进行了跟踪,直到2021年12月.
- 使用多变量考克斯比例危险模型,调整了人口,行为,并发症和抑郁因素.
主要成果:
- 与没有胰腺炎的人相比,患有任何胰腺炎的人的自杀死亡率更高 (0.82%) (0.35%).
- 慢性胰腺炎 (1.10%) 和急性胰腺炎 (0.89%) 均显示自杀死亡率高于非胰腺炎组.
- 调整后的模型显示,慢性胰腺炎 (HR 2.04) 和急性胰腺炎 (HR 1.69) 的自杀死亡风险增加.
结论:
- 慢性胰腺炎独立地与自杀死亡风险增加有关.
- 没有进展为慢性疾病的急性胰腺炎没有显示出明显增加自杀风险.
- 积极的精神治疗和胰腺炎并发症的管理对于降低受影响个体的自杀风险至关重要.
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