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治疗耐药自闭症的神经调节:系统性审查
Tag Alsir Osama1, Yusuke S Hori2, Jordan Vanleuven1
1Vanderbilt University School of Medicine, Nashville, TN, United States.
概括
神经调节和神经外科手术显示出治疗自闭症谱系障碍 (ASD) 中严重症状的前景. 当其他方法失败时,这些先进的干预措施可以为侵略性,自我伤害行为和社会缺陷提供潜在的缓解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经外科 神经外科
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出社会沟通挑战和重复性行为.
- 严重的攻击性,自我伤害行为 (SIB) 和强迫症症状发生在一些患有ASD的人身上.
- 传统的ASD治疗方法通常效果有限.
研究的目的:
- 系统地审查关于ASD神经调节和神经外科干预的临床文献.
- 为了评估深度大脑刺激 (DBS),rTMS,iTBS,tDCS和ASD的放射性手术的结果.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行全面的文献搜索,截至2025年12月.
- 包括报告ASD患者接受神经调节或废除手术的临床结果的研究.
主要成果:
- 十六项研究表明DBS,rTMS,iTBS,tDCS和放射性外科手术产生了积极的结果.
- 干预措施减少了侵略性,SIB和强迫症症状,改善了社会和执行功能.
- 在所有治疗方式中,不良事件通常是轻微的和短暂的.
结论:
- 神经调节和废除干预措施显示出治疗耐药ASD的治疗潜力.
- 这些方法对具有侵略性,SIB和社会认知缺陷的个体尤其有益.
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