对生物基和合成相变材料功能化同轴纤维用于光热控制药物输送的比较研究
Jianfeng Zhou1, Feng Xue2, Lili Xu2
1School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Biomaterials advances
|March 5, 2026
概括
这项研究开发了光热相变纤维膜,用于控制药物释放. 基于羊脂的羊肉膜 (F3) 显示了持续释放和出色的生物相容性,为精密医学提供了潜力.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 控制药物释放在生物医学中至关重要.
- 响应温度的系统提供非侵入性,触发释放.
- 光热材料可以精确地远程控制药物释放.
研究的目的:
- 准备和描述用于药物输送的光热相变同轴纤维膜.
- 评估开发的膜的药物释放特征,光热性能和生物相容性.
- 研究这些膜在精密医学应用中的潜力.
主要方法:
- 制造三种类型的同轴纤维膜 (F1,F2,F3) 使用不同的相变材料 (酸,四度醇,羊脂) 和MoS2.
- 使用SEM,TEM,XRD,FTIR,水接触角度和机械测试进行表征.
- 在体外释放药物的研究,近红外激光照射下的光热性能评估和生物相容性评估.
主要成果:
- 成功制备了不同直径的疏水性纤维膜.
- 基于羊脂的羊脂膜 (F3) 显示持续释放药物156小时,比F1和F2 (1小时) 长得多.
- F3表现出极好的光热稳定性,生物相容性和受温度和近红外激光照射影响的可控药物释放.
结论:
- 光热相变纤维膜,特别是基于羊脂的F3,显示出对受控和温度响应的药物递送有希望.
- F3膜提供持续的药物释放和良好的生物相容性,使其成为精密医学的潜在候选者.
- 这项技术为非侵入性,远程触发的药物输送系统提供了一种新的方法.
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