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在右轨道前皮层上的正管tDCS增强了亚临床强迫症患者转向以模型为基础的控制的能力

Zhongqiang Ruan¹, Ziyan Li¹, Xiaoshu Luo¹

¹Center for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science and School of Psychology, South China Normal University, Guangzhou, China; Key Laboratory of Brain, Cognition and Education Sciences, Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, China.

Journal of psychiatric research

|March 5, 2026

概括

在轨道前皮层 (OFC) 上进行的阴道跨直流刺激 (tDCS) 改善了强迫症 (OCD) 特征的个体的决策. 这种神经刺激增强了基于模型的控制,为强迫症提供了新的治疗途径.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
精神病学是一个精神病学.

背景情况:

轨道前皮层 (OFC) 刺激显示出强迫症障碍 (OCD) 的治疗前景.
关联OFC刺激与减少强迫行为的神经认知机制需要阐明.
基于模型 (MB) 和无模型 (MF) 的强化学习系统之间的受损仲裁与亚临床强迫症有关.

研究的目的:

研究跨直流刺激 (tDCS) 对亚临床强迫症OFC功能的影响.
检查OFC tDCS如何调节MB和MF强化学习系统之间的仲裁.
通过OFC刺激来确定强迫症治疗的潜在神经认知机制.

主要方法:

随机化,模拟控制试验,涉及具有高强迫症库存修订 (OCI-R) 评分的参与者.
对右侧OFC施加六次阳极,阴极或假装tDCS.
使用两步决策任务对仲裁控制进行评估,并对 MB-MF 动态在刺激前后进行计算建模.

主要成果:

在MB-最佳条件下 (p < 0.001) 正方形OFC tDCS显著增强了MB-MF转换的抑制.
这种增强促进了稳定的MB控制,表明了改进的仲裁.
与假刺激相比,阳道tDCS没有产生显著的效果.

结论:

右OFC阴极tDCS促进了适合上下文的MB策略实施,改善了亚临床强迫症中仲裁控制.
这一发现揭示了治疗强迫症的新治疗机制.
针对OFC的tDCS为强迫症相关疾病提供了一个有前途的非侵入性神经调节策略.

关键词:

对仲裁进行控制.强迫性行为是一种强迫性行为.轨道前额皮层的皮层.通过骨进行直流刺激.

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相关概念视频

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...