在胰腺癌中使用非耻辱化的支持性护理药物的种族差异
Olga Monika Trejos Kweyete1, Chardaé Whitner2, David L Deremer3
1Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Orlando, Florida.
Journal of pain and symptom management
|March 5, 2026
概括
在胰腺癌患者的支持性护理药物使用中存在种族差异. 例如,黑人患者使用反药和睡眠辅助剂的比例较低,这凸显了生命末期症状管理中的持续不平等.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 健康 公平 卫生 公平
背景情况:
- 胰腺癌 (PC) 呈现出显著的症状负担,影响生活质量.
- 支持性护理药物 (SCM) 对于管理PC症状至关重要.
- 以前的研究发现了SCM的种族差异,但对非耻辱化药物知之甚少.
研究的目的:
- 调查在使用非耻辱化的SCM时存在的种族和民族差异.
- 在终身期 (EOL) 期间检查PC患者中SCM的使用情况.
- 确定多样化的PC患者群体在支持性护理中的潜在不平等现象.
主要方法:
- 使用SEER-Medicare数据 (2005-2017年) 的回顾性队列研究.
- 纳入标准:PC患者,连续的医疗保险A,B,D部分覆盖,诊断后12个月内死亡.
- 特定药物类别的门诊处方要求定义了SCM的使用;多变量逻辑回归分析了差异.
主要成果:
- 这项研究包括了74,309名跨种族/种族群体的PC患者.
- 与白人患者相比,黑人患者使用的反药,头痛辅助药和睡眠辅助药的使用率较低.
- 黑人患者使用食欲兴奋剂和认知辅助剂的比例更高;在其他少数群体中观察到类似的模式.
结论:
- 证实了EOL PC患者在非耻辱化的SCM使用中存在持续的种族和种族差异.
- 这些发现强调了癌症症状管理中现有的不平等现象.
- 需要采取干预措施,确保所有不同患者群体均能平等获得SCM.
相关概念视频
Nursing Ethical Principles II
2.4K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
2.4K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
319
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
319
Chronic Pancreatitis II: Collaborative Care
447
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
447
Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K


