来自天然植物药物的抗痛风活性成分及其相关机制
Lewei Zhao1, Yishuo Zhu1, Juhua Zhong1
1College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Journal of ethnopharmacology
|March 5, 2026
概括
天然产品为治疗痛风性关节炎 (GA) 提供了一个有前途的途径,副作用较少. 本综述对植物衍生化合物及其机制进行了分类,确定了开发更安全,多目标疗法的关键剂.
科学领域:
- 药理学和民族植物学
- 自然产品化学 自然产品化学
- 类风湿病学 类风湿病学
背景情况:
- 痛风性关节炎 (GA) 在历史上已被公认,早期的治疗涉及自然疗法.
- 由于常规药物的潜在不良影响,对GA的更安全,长期药物治疗的需求至关重要.
- 自然产品提供了一个有前途的替代品,因为它们有利的安全性和多目标治疗潜力.
研究的目的:
- 综合审查和分类用于痛风性关节炎 (GA) 的植物提取物和单体化合物.
- 总结这些天然产品的抗痛风作用和潜在机制.
- 支持开发更安全,更有效的GA治疗替代方案.
主要方法:
- 在PubMed,Web of Science和CNKI数据库中的系统文献搜索 (1994年5月 - 2025年5月).
- 收集和分析关于用于治疗痛风性关节炎 (GA) 的天然产品的研究.
- 抗痛风活性成分及其作用机制的分类和总结.
主要成果:
- 确定了164种植物提取物和148种具有抗痛风活性的生物活性化合物.
- 主要的活性成分包括特类,多类和黄类.
- 机制包括尿酸减少,抗炎,抗氧化作用,信号通路调节,热和自.
结论:
- 本综述提供了用于GA处理的天然产品的首个全面分类.
- 阐明了这些自然剂的多样化机械路径.
- 为开发多目标GA治疗提供了一个框架,并确定了进一步研究的候选者.
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