环境暴露与中年和老年人认知功能的关联:一个嵌套的病例对照研究
Yu Shen1, Yuanyuan Liu2, Yue Sun3
1School of Environment and Spatial Informatics, China University of Mining & Technology, No.1, Daxue Road, Xuzhou, Jiangsu, 221116, China; Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; China CDC Key Laboratory of Environment and Human Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100021, China.
Environmental pollution (Barking, Essex : 1987)
|March 5, 2026
概括
环境,如合成性抗氧化剂 (SPA),与成年人的认知能力下降有关. 暴露于的混合物,特别是三甲基基 (TBHQ) 和基 (BHT),显著增加认知障碍的风险.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 全球老龄化人口面临越来越多的认知障碍患病率.
- 环境,包括像双和合成性抗氧化剂 (SPAs) 这样的内分泌干扰剂,是已知的神经毒性危险因素.
- 现有的研究将暴露与记忆力缺陷和神经发育问题联系起来,但对人口老龄化和混合物效应的数据有限.
研究的目的:
- 在45岁及以上的成年人中量化十种环境的尿液水平.
- 调查单一和联合暴露与认知功能之间的关联.
- 为了确定导致老年人认知障碍风险的特定成分.
主要方法:
- 在SCOPA-中国队列中的122名成年人 (≥45岁) 的尿中测量了醇水平.
- 认知功能被评估使用迷你精神状态检查 (MMSE).
- 统计模型包括多变量条件逻辑回归 (CLRM),加权量子素总回归 (WQS),贝叶斯核机回归 (BKMR) 和量子素g计算 (qgcomp) 用于分析关联.
主要成果:
- 较高的三甲基 (TBHQ) 和4,4'-二基乙烯 (DHDPE) 暴露水平与认知障碍风险增加有关.
- 混合物显著增加了认知障碍的风险,TBHQ,DHDPE和丁酸醇 (BHT) 占总风险的83%.
- BKMR和qgcomp分析证实了与混合物相关的风险,确定BHT,TBHQ和DHDPE是认知能力下降的关键驱动因素.
结论:
- 暴露于SPAs (TBHQ,BHT) 和DHDPE与中年和老年人的认知能力下降有关.
- 环境中的混合物具有显著的神经毒性风险,有助于认知障碍.
- 进一步的研究和公共卫生策略是有必要的,以减轻这些有害的暴露.
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