对抗PD-1免疫疗法的抗性治疗III和IV阶段黑色素瘤:全球图表综述研究
Elizabeth M Gaughan1, Miso Kim2, Ignacio Mendez3
1University of Virginia Cancer Center, Charlottesville, Virginia, USA.
Journal for immunotherapy of cancer
|March 5, 2026
概括
有相当数量的黑色素瘤患者对抗编程细胞死亡蛋白1 (PD-1) 免疫疗法产生抗性. 现实世界的数据证实了临床医生可靠地评估进展,识别与耐药性相关的因素.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 黑色素瘤研究 黑色素瘤研究
背景情况:
- 反编程细胞死亡蛋白1 (PD-1) 免疫疗法改变了黑色素瘤的治疗方法.
- 了解耐药机制对于开发有效的组合疗法至关重要.
研究的目的:
- 在黑色素瘤患者中表征抗PD-1抗药性模式.
- 评估临床评估与疾病进展的独立中央审查之间的一致性.
主要方法:
- 对接受抗PD-1治疗的738名III/IV阶段黑色素瘤患者的回顾性图表审查.
- 使用癌症免疫疗法协会标准对抗性的分类.
- 分析耐药性 (TTR) 和整体存活时间;计算临床医生指定的进展的积极预测值 (PPV).
主要成果:
- 观察到大量的耐药性和晚期进展率:47.1%在辅助剂和67.5%在高级设置中.
- 抵抗模式因国家,种族,BRAF突变和PD-L1表达而异.
- 临床对进展的评估显示PPV为87.2%.
结论:
- 对于管理黑色素瘤中抗PD-1耐药性的存在重大未满足的需求.
- 在现实世界中对进展的临床评估是可靠的.
- 与耐药性相关的已识别的因素需要进一步调查风险分层.
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