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在先天性细胞巨乳病毒感染中的小脑形

Marcus Meneses¹, Amirreza Manteghinejad², Alka Gupta²

¹From the Department of Radiology (M.M., A.M., C.R.C.-V., S.R.T., M.T.W.), Children's Hospital of Philadelphia, Perelman School of Medicine (M.T.W.), University of Pennsylvania, Philadelphia, PA, USA and Neuroradiology (A.G.), SUNY Upstate Medical University, Syracuse, NY, USA. silvadecam@chop.edu.

AJNR. American journal of neuroradiology

|March 5, 2026

概括

先天性细胞巨乳病毒 (cCMV) 可以导致小脑形,这些形比以前认为的更常见. 这些通过MRI识别的发现总是伴随着其他典型的cCMV成像特征.

科学领域:

神经辐射学神经辐射学
儿科神经学儿科神经学
传染性疾病传染性疾病

背景情况:

在美国,先天性细胞巨乳病毒 (cCMV) 是导致出生缺陷的主要传染病原因.
在cCMV文献中,小脑异常很少被报道.
在cCMV中神经成像的发现是多样化的,需要全面的理解.

研究的目的:

详细说明cCMV中小脑异常和形的频谱.
将这些小脑发现与其他典型的cCMV成像特征联系起来.
在cCMV中分析产前和产后大脑MRI发现.

主要方法:

在四级儿童医院进行了回顾性观察性研究.
包括已确认cCMV和胎儿/产后大脑MRI的患者.
两个神经放射学家对小脑形态和常见cCMV特征的评估.

主要成果:

在58.8%的胎儿和57.9%的产后cCMVMRI中观察到大脑小脑形.
与对照组相比,在产后cCMVMRI中,体的高度和直径较小.
所有患有小脑异常的病例也呈现出其他典型的cCMV成像发现.

结论:

小脑形是cCMV比以前认为的更为普遍的特征.
在所有疑似cCMV病例中,应仔细评估MRI上的小脑异常.
这些发现强调了在cCMV诊断中进行彻底小脑评估的重要性.

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