ERS技术标准 - 心肺运动测试的参考值:总结报告和呼吁采取行动
Thomas Radtke1,2, Luis Chávez3, Lauren Duggan3
1Department of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
The European respiratory journal
|March 5, 2026
概括
开发心肺运动测试 (CPET) 结果的全球参考范围,如氧气吸收峰值 (VO2峰值),因数据异质性显著而受到阻碍. 未来的努力需要标准化协议,以获得可靠的CPET参考值.
科学领域:
- 运动生理学 运动生理学
- 临床测量 临床测量
- 生物统计学 生物统计学
背景情况:
- 心肺运动测试 (CPET) 对于评估对运动的生理反应和识别限制至关重要.
- 对于CPET结果的现有参考方程是特定于人群的,不涵盖全人类年龄范围.
- 建立CPET的全球,所有年龄段的参考范围是一个重要的临床需求.
研究的目的:
- 导出全球肺功能倡议 (GLI) 对人类年龄跨度内的健康个体的峰值氧气吸收 (VO2峰值) 和峰值工作率 (Wpeak) 的参考方程.
- 调查创建CPET结果的通用参考范围的可行性.
主要方法:
- 来自17个国际地点的5956名年龄在6-83岁之间的健康个体的CPET数据的回顾性收集.
- 使用的定位,尺度和形状 (GAMLSS) 的通用添加模型,包括年龄,性别,身高和体重.
- 检查了地理区域,设备,测试协议和数据平均化方法对峰值运动变量的影响.
主要成果:
- 在VO2峰值和W峰值中观察到实质性的受试者之间的变异性,在各年龄组之间有广泛的置信区间.
- VO2峰值的异质性与地理区域,代谢车型和平均方法有关.
- 虽然控制这些因素改善了模型的合适性,但它们不足以可靠地预测参考范围.
结论:
- 测试地点之间CPET方法和结果的显著异质性阻止了开发可靠的VO2峰值和W峰值参考范围.
- 建议采用标准化协议和集中分析进行前性数据收集的框架.
- 该框架旨在减少变异性,并为CPET结果建立可靠,临床上有意义的参考范围.
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