在简单疹病毒1型角膜炎的治疗失败
Anna C Randag1, Georges Mgm Verjans2, Lies Remeijer3
1Cornea and External Diseases Department, Rotterdam Eye Hospital, Rotterdam, The Netherlands a.randag@oogziekenhuis.nl.
The British journal of ophthalmology
|March 5, 2026
概括
抗阿西克洛维尔的简单疹病毒1型 (HSV-1) 角膜炎很少见,但具有挑战性. 本综述探讨了HSV-1角膜炎的发病原因,治疗失败的原因以及耐药病例的选择.
科学领域:
- 眼科医生 眼科 眼科
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 简单疹病毒1型 (HSV-1) 通常会导致眼睛的复发性感染 (角膜炎).
- 目前的治疗包括核类类似物,如阿西克洛维尔 (ACV),通常与皮质类固醇.
- 治疗失败可能源于坚持问题,错误的剂量,误诊,共感染或药物耐药性.
研究的目的:
- 为了审查HSV-1角质炎的发病过程.
- 定义和探索HSV-1角质炎治疗失败的原因.
- 讨论抗阿西克洛维尔抗性 (ACVR) HSV-1角质炎的发展和管理.
主要方法:
- 关于HSV-1角膜炎病原和治疗的文献综述.
- 分析导致治疗失败的因素.
- 检查ACV耐药机制和治疗策略.
主要成果:
- 抗阿西克洛维尔耐药性 (ACVR) 发生在约6%的免疫能力强的HSV-1角质炎患者中.
- 抗ACV耐药性损害了标准抗病毒疗法的有效性.
- 确定治疗失败的原因对于有效管理至关重要.
结论:
- 了解HSV-1角质炎的发病因子是治疗失败的关键.
- 对于耐火病例,需要进行系统的处理.
- 对ACVR HSV-1角膜炎需要新的治疗策略,以防止疾病的进展.
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