化学辐射后治疗失败的不同模式 在p16+和p16-之间 受口腔癌影响的患者
Riccardo Gili1,2, Paolo Bossi3, Luca Lalli4
1Medical Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Head & neck
|March 5, 2026
概括
口腔癌的复发因HPV状况和吸烟而有所不同. 阳性HPV重度吸烟者面临更高的远程转移风险和更差的生存率,需要高级风险分层.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症研究研究
- 临床流行病学临床流行病学
背景情况:
- 口癌 (OPC) 的临床行为因人乳头瘤病毒 (HPV) /p16状态和吸烟而有所不同.
- 阳性OPC通常具有更好的生存率,但复发模式尚未完全理解.
研究的目的:
- 调查HPV/p16状态和吸烟史如何影响口腔癌复发模式.
- 为了在不同患者子组中比较无疾病生存率 (DFS),总生存率 (OS) 和复发后生存率 (rOS).
主要方法:
- 对674名AJCC VII阶段III-IVa/b OPC患者的回顾性分析,这些患者接受了强度调节终极辐射疗法 (IMRT),有或没有全身疗法.
- 在14个南欧中心进行的多中心研究,根据p16状态和吸烟类别对复发模式,DFS,OS和ROS进行比较.
主要成果:
- 阳性HPV瘤的远程复发率更高,特别是在重度吸烟者中.
- 负p16的OPC主要表现为局部区域性失败.
- 在p16阳性患者中,显著改善了DFS,OS和rOS.
结论:
- 在OPC中,复发模式受到HPV状态和吸烟史的显著影响.
- 阳性HPV重度吸烟者构成了高危子组,远程转移增加,生存结果更差.
- 目前的p16状态可能不足以进行风险分层;对于这个子组,需要精确的方法.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
12.4K
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
10.3K
相关概念视频
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
02:49Cancer Therapies
10.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.5K