一个肠道微生物群-脏-心脏轴预测未来的心血管疾病
Kanta Chechi1,2,3, Rima Chakaroun4,5,6, Antonis Myridakis7
1Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom. k.chechi@imperial.ac.uk.
Nature communications
|March 5, 2026
概括
肠道微生物影响心脏和脏健康. 芳香氨基酸的代谢物将肠道细菌与心脏功能和心血管疾病 (CVD) 风险联系起来.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢学 代谢学 代谢学
背景情况:
- 心血管疾病 (CVD) 是全球健康的重大负担.
- 早期发现CVD发病和进展的标志物至关重要.
- 以前的研究表明,肠道微生物群与代谢障碍/心血管疾病之间存在关联.
研究的目的:
- 调查肠道微生物组变化与心脏和功能亚临床变化之间的关联.
- 为了确定特定的微生物代谢物参与肠道微生物-心血管轴.
- 探索这些代谢物在预测发生心血管疾病中的作用.
主要方法:
- 在一个代谢健康的欧洲队列中分析肠道微生物组相关的代谢物.
- 代谢物水平与心脏功能的生物标志物 (亲心房 natriuretic ) 和功能 (估计的膜过率) 的相关性.
- 利用观察和遗传数据建立调解并评估外部加拿大队列中发生的心血管疾病风险.
主要成果:
- 与肠道微生物的芳香氨基酸 (氨酸,氨酸) 代谢相关的代谢物与心脏和功能标志物有关.
- 这些与微生物组相关的代谢物被确定为肠道微生物组-脏轴的媒介.
- 这些代谢物的基线水平预测了单独人群中发生的心血管疾病.
结论:
- 肠道微生物群与心轴相互作用,表明器官间的交叉通话.
- 微生物组衍生代谢物在心血管和脏健康中发挥作用.
- 这些发现突出了肠道微生物群作为CVD风险评估和干预的潜在目标.
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