在功率和位置不确定性下,间歇光动力疗法治疗规划的稳定性在光输送中的不确定性下
Shuran Wang1, Tina Saeidi2, Lothar Lilge2,3
1Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Rd, Toronto, ON, M5S3G8, Canada. shuran.wang@mail.utoronto.ca.
Scientific reports
|March 5, 2026
概括
模拟显示,光功率的变化对质母细胞瘤的间歇光动力疗法 (iPDT) 的影响最小. 然而,源位置错误显著影响处理,但可以通过PDT-SPACE等规划工具来减轻.
科学领域:
- 医学物理 医学物理
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 间歇性光动力学疗法 (iPDT) 依赖于精确的光剂量输送.
- 由于生物和物理的不确定性,在iPDT中预测临床结果具有挑战性.
- 光输送的不准确性,包括功率波动和源定位错误,冲击处理的有效性.
研究的目的:
- 分析光源功率变化和位置偏差对质母细胞瘤iPDT结果的影响.
- 评估PDT-SPACE规划工具在缓解这些不确定性方面的有效性.
- 确定优化iPDT治疗稳定性的策略.
主要方法:
- 计算机模拟使用虚拟质母细胞瘤模型.
- 建模光源功率不确定性 ([公式:见文本],[公式:见文本],[公式:见文本]) 和位置偏差 (高达[公式:见文本]角误差).
- 使用和评估PDT-SPACE规划工具,其中包括新的功率不确定性意识选项和源位置优化.
主要成果:
- 电力不确定性对瘤覆盖率的影响很小,最坏情况的差异不超过[公式:见文本].
- 位置不确定性显著降低了瘤覆盖率,但重新优化将其恢复到[公式:参见文本].
- PDT-SPACE 改善了最坏情况下的最低覆盖范围,达到 [公式:见文本] ,并减少了健康组织的损伤,达到 [公式:见文本].
结论:
- 光源功率变化在IPDT中对质母细胞瘤构成较小的风险.
- 位置偏差是错误的重要来源,但可以通过重新优化策略来管理.
- 在PDT-SPACE等工具中将功率和位置优化结合起来,可以提高治疗的稳定性,并最大限度地减少iPDT中的光传递错误.
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