心理药物与双相情感障碍中认知功能之间的关联
Faith Dickerson1,2, Andrea Origoni3, Emily Katsafanas3
1The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA. fdickerson@sheppardpratt.org.
International journal of bipolar disorders
|March 5, 2026
概括
一些双相情感障碍药物,包括齐普拉西,热素和克洛纳泽帕姆,与认知功能下降有关. 医生在为双相情感障碍患者开处方时应考虑这些影响.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双极性障碍通常涉及认知缺陷,即使在稳定的情绪状态.
- 精神药物是标准治疗方法,但它们对认知影响的研究不足.
研究的目的:
- 研究特定精神药物和双相情感障碍患者的认知功能之间的独立关联.
- 探索这些药物对认知表现的剂量依赖性影响.
主要方法:
- 利用机器学习 (cross-fit LASSO回归) 来分析567名双相情感障碍患者的认知测试成绩 (RBANS,Trails A,字母数序).
- 员工下令进行后勤回归,以评估药物剂量对认知的影响,控制共变量.
主要成果:
- 齐普拉西,热素和克洛纳泽帕姆独立地与显著较低的认知分数相关.
- 热素与所有认知指标都显示出剂量反应关系.
- 记忆和精神运动速度是受影响最严重的认知领域.
结论:
- 临床医生应考虑在双相情感障碍治疗中对齐普拉西,奔和克罗纳泽帕姆的认知副作用.
- 需要进一步的干预来提高双相情感障碍患者的认知功能和生活质量.
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