术前预后营养指数及其对剖腹产后手术部位感染的影响:回顾性病例控制分析
Karolin Ohanoglu Cetinel1, Alperen İnce2, Bugra Tunc3
1Department of Obstetrics and Gynecology, Republic of Turkey Ministry of Health, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Archives of gynecology and obstetrics
|March 5, 2026
概括
在剖腹产患者中,术前较低的预后营养指数 (PNI) 与更严重的手术部位感染 (SSI) 和炎症有关,尽管这不是一个独立的预测因素. 营养状况可以指导SSI的风险评估.
科学领域:
- 产科和妇科 产科和妇科
- 手术感染 手术感染
- 营养科学 营养科学
背景情况:
- 手术部位感染 (SSI) 是剖腹产后的严重并发症,导致孕产妇发病率增加,住院时间延长,医疗费用增加.
- 虽然已知SSI的各种风险因素,但母亲营养状况的具体影响,特别是预后营养指数 (PNI),在产科手术的背景下仍未得到充分研究.
研究的目的:
- 研究通过预后营养指数 (PNI) 评估的手术前母亲营养状况与剖腹产后手术部位感染 (SSI) 的发生和严重程度之间的关联.
- 在接受剖腹产的妇女中探索PNI,SSI状态,感染严重程度和炎症标志物之间的关系.
主要方法:
- 一项追溯病例控制研究,涉及190名经过剖腹产分娩的妇女.
- 在手术前24小时内使用血清白蛋白和淋巴细胞计数计算术前PNI.
- 分析了人口统计,外科手术前期和手术后期的数据,以评估与SSI的关联,感染严重程度以及像C反应蛋白 (CRP) 这样的炎症标志物.
主要成果:
- 较低的手术前PNI值与SSI严重程度的增加有关,需要广泛的抗生素,更长的住院时间和更高的术后CRP水平.
- 在SSI患者中发现PNI和CRP之间存在显著的逆相关性 (r = -0.338,p = 0.001).
- 虽然PNI不是SSI的独立预测因素,但更长的手术时间和吸烟被确定为SSI的风险因素.
结论:
- 虽然不是一个独立的预测指标,但较低的PNI值与更大的SSI严重性和全身炎症密切相关.
- 将PNI纳入术前风险评估,与BMI和手术时间一起,可以帮助识别剖腹产高风险妇女.
- 建议进行进一步的前性研究,以验证这些发现,并评估营养优化对术后结果的好处.
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