相关实验视频

Updated: Mar 7, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

FFAR4通过阻断氧化酸化来负面调节结直肠癌的生长

Lengyun Wei¹, Wei Wei², Qun Wang¹

¹School of Life Science, Anhui Medical University, Hefei, 230032, China.

Journal of translational medicine

|March 5, 2026

概括

G蛋白结合受体FFAR4 (自由脂肪酸受体4) 通过影响线粒体功能和新陈代谢来抑制结肠直肠癌 (CRC) 的生长. 这一发现凸显了FFAR4作为CRC的诊断生物标志物和治疗点的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
代谢过程中的代谢.

背景情况:

大肠直肠癌 (CRC) 与饮食和遗传学有关.
自由脂肪酸受体 (FFARs) 可能会在癌症中调解食脂肪酸的影响.
目前尚不清楚FFAR4在CRC病原发生中的具体作用.

研究的目的:

研究FFAR4在结直肠癌中的作用.
确定FFAR4作为CRC的诊断生物标志物和治疗点的潜力.

主要方法:

利用整合式多态学来识别CRC中的FFAR4.
在CRC组织中分析FFAR4表达和临床相关性,使用转录组数据,ROC分析和免疫光.
通过在CRC细胞系中与TUG891进行药理激活来评估FFAR4的功能,以及一个综原性瘤模型,包括增殖,细胞循环和代谢评估.

主要成果:

在CRC组织中,FFAR4表达量下降,较高的水平与改善的生存率相关.
在体外,FFAR4激活抑制了CRC细胞增殖和诱导细胞循环停止,并在体内减少了瘤生长.
FFAR4的激活导致线粒体呼吸能力下降,改变了NADH氧化还原平衡,并增加了糖溶性活性,这表明了补偿机制.

结论:

FFAR4通过调节线粒体功能和细胞代谢来抑制CRC进展.
FFAR4显示出作为CRC的诊断生物标志物的潜力.
在结直肠癌治疗中,FFAR4是一个有前途的治疗策略.

关键词:

结肠直肠癌是一种癌症.在FFAR4FFAR4 氧化酸化是一种氧化酸化.在TUG891中.

更多相关视频

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog

Published on: November 5, 2014

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

相关概念视频

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...