通过社区药物检查检测出意想不到的药物后的降低风险行为:一个横截面研究
Samuel Tobias1,2, Cameron Grant1, Mark Lysyshyn2,3
1British Columbia Centre on Substance Use, 400-1190 Hornby Street, Vancouver, BC, V6Z 2K5, Canada.
Harm reduction journal
|March 5, 2026
概括
社区药物检查服务帮助人们降低风险. 在阿片类药物样本中发现意想不到的物质,如二胺,增加了采用更安全的药物使用实践的可能性.
科学领域:
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
- 社会学 社会学 社会学
背景情况:
- 基于社区的药物检查服务正在扩大,以应对北美不受监管的药物毒性危机.
- 这项研究研究了鉴定出意想不到的活性药物与随后的降低风险行为之间的联系.
研究的目的:
- 评估药物检查服务分析样本中检测出意想不到的活性药物与参与减少危害实践之间的关系.
- 了解识别未知的化合物如何影响用户行为.
主要方法:
- 一项横截面研究分析了加拿大不列颠哥伦比亚省使用社区药物检查服务的447人 (2020年3月至2024年7月) 的数据.
- 使用多变量逻辑回归模型来检查检测出意想不到的活性药物 (例如,类药物) 与随后的风险降低实践 (例如,剂量降低,药物处置) 之间的关联.
- 药物样本使用里埃变换红外光谱和免疫试验条进行分析.
主要成果:
- 在447名参与者中,174名 (38.9%) 在阿片类药物样本中检测到意想不到的活性药物,最常见的是二.
- 报告的主要降低风险行为是药物处置 (n=24) 和剂量减少 (n=11).
- 在检测出意想不到的活性药物和从事降低风险的实践之间发现了显著的积极关联 (aOR=2.24;95% CI:1.30-3.87).
结论:
- 在样本中发现意想不到的活性药物的人更有可能采取降低风险的行为.
- 药物检查服务作为一种有价值的危害减少工具,帮助个人在不可预测和不受监管的药物供应中进行导航.
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