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Updated: Mar 7, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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如何在使用自然史数据的SCA2患者试验中提高统计能力?

Maylis Tran1, Pierre-Emmanuel Poulet2, Emilien Petit2

  • 1Sorbonne University, Paris Brain Institute (ICM), INSERM, INRIA, CNRS, APHP, Paris, France. maylis.tran@icm-institute.org.

Trials
|March 5, 2026
PubMed
概括

新的统计方法提高了罕见疾病的临床试验能力. 临床试验预测推断 (PPCT) 和类似的方法通过使用自然史数据来更好地估计治疗效果,从而减少样本大小的需求.

关键词:
临床试验的设计数字双胞胎是一个数字双胞胎.外部数据 外部数据自然历史数据自然历史数据临床试验的预测驱动推断 (PPCT)预测协变量调整的预测.预测得分方法的方法.统计能力增加 统计能力增加

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