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通过结肠挥发性脂肪酸的整合性聚类揭示了断奶小猪的微生物群和宿主生理变异

Chengcheng Li¹, Stijn Heirbaut¹, Joris Michiels¹

¹Laboratory for Animal Nutrition and Animal Product Quality, Department of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent, 9000, Belgium.

Journal of animal science and biotechnology

|March 5, 2026

概括

小猪中明显的挥发性脂肪酸 (VFA) 概况显示了两个表型:高短链脂肪酸 (HSCFA) 与更好的肠道健康和生长有关,高分支链脂肪酸 (HBCFA) 与降低性能有关.

科学领域:

动物科学动物科学
微生物学微生物学
代谢学代谢学代谢学

背景情况:

挥发性脂肪酸 (VFA) 是关键的微生物发酵产物,连接肠道微生物群,宿主代谢和生理学.
内源性VFA概况及其在断奶小猪体内的生理相关性需要进一步的描述.

研究的目的:

在断奶小猪中识别不同的VFA表型.
将微生物发酵模式与肠道新陈代谢,动物健康和表现联系起来.

主要方法:

综合了来自六项独立试验的数据,其中包括164只被断奶的小猪.
应用的k-means聚类到六个VFA在结肠消化器中,以定义代谢物表型.
利用XGBoost分类模型将肠道微生物群组成与VFA表型联系起来.

主要成果:

确定了两个VFA表型:高短链脂肪酸 (HSCFA) 和高分支链脂肪酸 (HBCFA).
HSCFA组表现出更高的VFA,更低的氨/尿素,更高的高度,更低的结肠pH值,以及改善的生长性能 (体重,平均每日增长).
HBCFA组表现出更高的分支链脂肪酸,氨和特定细菌的丰富 (例如,Escherichia-Shigella,Prevotella).

结论:

结肠VFA概况定义了不同的微生物和生理模式,影响小猪的肠道功能和生长.
在HSCFA表型表明有利的肠道环境有有益的微生物和发酵产品.
结肠中的蛋白质发酵与HBCFA表型相关,与动物性能降低相关.

关键词:

分支链脂肪酸分支链脂肪酸微生物群中的微生物群短链脂肪酸短链脂肪酸断奶的猪仔已经开始了.

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