与抗生素混合的骨质水泥的形态特性
Danica Popovska1, Ivan Boev, Maja Ristova Delipetrev
1Clinic for Orthopedic Diseases, University Clinic for Traumatology, Orthopedics, Anesthesia, Reanimation, Intensive Care and Emergency Center, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of North Macedonia; doncovska@yahoo.co.uk.
概括
这项研究揭示了如何添加抗生素,如万科米到多甲基酸) 骨水泥改变其结构和多孔性. 衰老会导致大量的抗生素释放,影响水泥的完整性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 整形外科手术 整形外科手术
背景情况:
- 聚甲基酸 (PMMA) 骨头水泥在骨科手术中广泛使用.
- 将抗生素纳入骨质水泥对于预防手术部位感染至关重要.
- 了解抗生素对PMMA水泥的形态影响对于优化临床性能至关重要.
研究的目的:
- 为了研究手动装载的PMMA骨水泥与美罗和万科迈的形态变化.
- 分析抗生素颗粒与PMMA矩阵之间的相互作用.
- 评估水泥老化和化过程中的结构变化.
主要方法:
- 扫描电子显微镜 (SEM) 用于检查PMMA骨质水泥样品.
- 样品包括手动混合的SmartSet EnduranceTM MV骨质水泥与美罗,万科米辛,或两者.
- 在Ringer溶液中潜伏24小时28天后进行了微观结构分析.
主要成果:
- 手工制备的PMMA骨质水泥表现出高达65微米的微孔性,具有均的结构.
- 化28天没有显著改变聚合物结构,但在应力下诱导裂纹.
- 添加万科素增加了水泥的孔隙性和孔隙不规则性,干扰了聚合物形成.
- 28天后,抗生素颗粒在很大程度上从表面释放出来,与vancomycin相比,meropenem的释放率更高.
结论:
- 范科米辛显著影响PMMA骨形态,增加多孔性和不规则性.
- 水泥老化导致大量的抗生素颗粒的释放,特别是美罗.
- 这些发现强调了需要考虑抗生素诱导的形态变化,以改善骨质水泥配方.
相关概念视频
01:18The Bone Matrix
6.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
6.2K
01:22Waterproofing and Anti-Bacterial Admixtures in Concrete
268
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
268
01:40Bone Remodeling
40.8K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.8K
01:31Essential Minerals for Bone Health
6.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.9K
01:23Bone as Supporting Connective Tissue
7.7K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
7.7K