癌症幸存者中的症状群和症状负担
Marilyn J Hammer1, Carolyn Harris2, Rachel Pozzar1
1Dana-Farber Cancer Institute and Northeastern University, Boston, Massachusetts, USA.
Cancer medicine
|March 6, 2026
概括
癌症幸存者经历了显著的症状负担,平均有十个同时出现的症状. 年轻人,女性和转移性疾病患者面临更高的风险,这凸显了针对已识别的症状集群进行有针对性的干预的必要性.
科学领域:
- 在瘤学瘤学.
- 癌症生存率研究 癌症生存率研究
- 症状管理 症状管理
背景情况:
- 关于癌症幸存者的症状负担和集群的数据有限.
- 了解这些经验对于改善治疗后生活质量至关重要.
研究的目的:
- 描述癌症幸存者的44种症状的发生,严重程度和痛苦.
- 为了确定更高症状负担的风险因素.
- 用发生率来评估不同的症状集群.
主要方法:
- 1147名癌症幸存者完成了一项在线调查,使用纪念症状评估尺度评估44种症状.
- 多变量回归确定了症状负担的风险因素.
- 探索性因子分析揭示了基于发生的症状集群.
主要成果:
- 幸存者报告平均有十个同时出现的症状.
- 年龄较小,女性性别,并发病,转移性疾病和功能状况较差增加了症状负担的风险.
- 确定了六个症状集群:心理,癌症/治疗相关,呼吸,疼痛,减肥和上皮.
结论:
- 需要进一步的研究来确认症状和集群流行,并确定更多的风险因素.
- 了解症状集群背后的机制至关重要.
- 开发针对癌症类型的特定症状集群的有针对性的干预措施是未来的优先事项.
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