血清元素驱动的肠道微生物乱及其对妊娠期失脂症的预测影响:一个潜在的出生队列研究
Anan Zhou1,2, Bowen Jin3,4, Jing Lu3,4
1Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Environmental science & technology
|March 6, 2026
概括
母体血清金属和肠道微生物相互作用,影响怀孕期间的脂质水平. 这种相互作用可以预测妊娠期脱脂症,有助于早期风险识别和预防策略.
科学领域:
- 生殖生物学 生殖生物学
- 代谢健康 代谢健康
- 微生物组研究的研究.
背景情况:
- 怀孕涉及显著的生理变化,包括母亲血清元素和肠道微生物群的变化.
- 这些变化可能会破坏新陈代谢平衡,但它们在妊娠期间对脂质调节的联合作用尚不清楚.
研究的目的:
- 调查母亲血清金属元素和肠道微生物群在怀孕中期到晚期脱脂症发展中的相互作用.
- 开发一种模型,用于早期预测妊娠性脂质失调症的风险.
主要方法:
- 在689名孕妇中分析了血清金属水平和肠道微生物群组成 (16SrRNA测序).
- 用可解释机器学习和因果推理方法来探索相互作用.
- 开发了一个CatBoost模型来预测晚期妊娠性脂质失调症.
主要成果:
- 血清铜和的升高与不良的脂质样本有关,而则显示出相反的关联.
- 金属影响了微生物的组成和多样性,与较高的甘油三酸相关的α多样性减少.
- 该预测模型使用怀孕中期的数据实现了高准确性 (AUC = 0.91,AP = 0.94).
结论:
- 母体血清元素和肠道微生物群协同促进妊娠性脂质失调症.
- 这些发现突出了潜在的生物标志物和治疗点,用于早期检测和预防怀孕期间的失脂症.
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