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作为抗癌剂的鱼类衍生抗微生物 (AMP):体外证据的小审查

Muhammad Akram Mohd Noordin¹, Ahmed Abdulkareem Najm^2,3, Herryawan Ryadi Eziwar Dyari^4,5

¹Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.

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|March 6, 2026

概括

海洋鱼类抗微生物 (AMP) 通过诱导癌细胞死亡,显示出显著的抗癌潜力. 进一步的研究和开发可能会导致从这些天然化合物中提取的新型癌症疗法.

科学领域:

海洋生物学海洋生物学
生物化学生物化学
在瘤学瘤学.

背景情况:

海洋鱼类是抗微生物 (AMP) 的丰富来源.
这些因其潜在的抗癌性质而引起人们的注意.

研究的目的:

审查最近 (2020-2024) 关于鱼类衍生AMP在抗癌应用中的研究.
突出这些化合物的机制和治疗前景.

主要方法:

来自主要科学数据库的研究文献综述.
从15篇相关研究论文中识别和综合发现.

主要成果:

鱼类AMP对各种癌症细胞系表现出广泛的抗癌活性.
机制包括通过ROS生成诱导亡/亡,线粒体功能障碍和DNA损伤.

结论:

由于选择性细胞毒性和诱导细胞死亡的能力,鱼类AMP提供了治疗前景.
未来的临床使用需要合成优化和先进的药物输送系统,以提高疗效.

关键词:

抗微生物是一种抗微生物.修复DNA的修复DNA的修复这是一种抗癌药物.亡 (apoptosis) 是一种死亡的过程.生物活性的生物活性.化学疗法化疗化疗鱼类鱼类鱼类鱼类的鱼类鱼类.

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