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整合蛋白质组学分析以确定AMPK作为TCM配方的关键标途径,用于高脂肪饮食诱导小鼠肥胖

Yu-Ju Chen¹, De-Shan Ning², Ching-Chiung Wang^1,3,4,5

¹Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.

Journal of traditional and complementary medicine

|March 6, 2026

概括

利夫苏斯正宗草药配方 (LAH) 通过激活AMPK通路并增强抗氧化剂防御,有效治疗肥胖症. 这种传统中医药可以减轻体重并改善代谢参数,为代谢障碍提供了一种新的治疗方法.

科学领域:

代谢障碍代谢障碍代谢障碍
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

通过Livsooth正宗草药配方 (LAH) 确立了非酒精性脂肪性肝病 (NAFLD) 的预防.
在治疗肥胖症中,LAH的有效性和机制需要阐明.

研究的目的:

研究LAH对高脂肪饮食 (HFD) 诱导的小鼠肥胖的治疗效果.
阐明LAH调节代谢途径的多目标机制.

主要方法:

网络药理学确定了19种化学成分和605个标,突出了AMPK途径.
蛋白质组学和体外研究分析了分子机制.
由HFD引起的肥胖小鼠接受了10周的LAH (615和2460毫克/公斤) 治疗.

主要成果:

治疗LAH可以减少16.55%的体重,并改善关键的代谢参数 (葡萄糖,甘油三,胆固醇).
LAH显著改善了肝功能,降低了ALT和AST水平,并逆转了氧化应激.
蛋白质组学揭示了LAH调节脂质代谢和抗氧化防御中的关键蛋白质,与AMPK通路有关.

结论:

LAH激活AMPK通路,降低FAS和SREBP1的调节,并增强抗氧化酶活性.
这些作用促进体重减轻和改善肝脂代谢,支持LAH作为治疗肥胖和代谢障碍的治疗剂.

关键词:

在 AMPK 路径上.草本补充剂是基于草本的补充剂.网络药理学网络药理学肥胖问题肥胖问题蛋白质组学分析

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