酸奶摄入对肠道微生物群的因果影响:欧洲孟德尔随机化研究
Mengqi Yang1, Liping Wang2, Peng Zhou2
1Department of General Surgery, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
International journal of genomics
|March 6, 2026
概括
酸奶的摄入因果影响肠道微生物群的组成,增加有益的细菌,如海莫菲勒斯和减少其他. 低脂酸奶特别增强了Eubacterium ruminantium和Methanobacteriaceae,影响了肠道健康.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 遗传学 是一个遗传学.
背景情况:
- 酸奶消费与肠道健康有关,但缺乏因果关系的证据.
- 酸奶对肠道微生物群组成的确切影响需要阐明.
- 了解这些关系可以为肠道健康的饮食建议提供信息.
研究的目的:
- 调查酸奶摄入量与肠道微生物群组成之间的因果关系.
- 为了区分低脂和全脂酸奶对特定细菌种群的影响.
- 为了利用大规模的遗传数据进行强有力的因果推断.
主要方法:
- 使用英国生物银行和MiBioGen数据进行孟德尔随机化分析.
- 使用逆方差加权和MR埃格尔方法.
- 评估了196种肠道微生物群和酸奶消费的因果关系.
主要成果:
- 酸奶的摄入显示了因果关联与增加的Haemophilus,Clostridium sensu stricto_1和Peptostreptococcaceae.
- 酸奶的摄入量与减少了鲁米诺科卡ceae UCG-011,贝塔蛋白细菌和比洛菲拉的摄入量有关.
- 低脂酸奶的摄入导致了Eubacterium ruminantium和Methanobacteriaceae的增加.
结论:
- 酸奶消费因果性地改变了肠道微生物群,对低脂肪品种有特殊影响.
- 研究结果表明酸奶在调节肠道微生物平衡中的作用.
- 进一步的研究可以探索这些酸奶诱导的微生物转移对健康的影响.
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