评估便微生物群概况与儿科患者的临床表现之间的相关性
Nastaran Asri1, Mohadeseh Mahmoudi Ghehsareh2, Fahimeh Sadat Gholam-Mostafaei2
1Student Research Committee, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Middle East journal of digestive diseases
|March 6, 2026
概括
儿童乳病患者的肠道微生物群与胃肠道和非胃肠道症状有关. 特定的细菌与腹,吐,减肥和疲劳相关,突出显示微生物群.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 乳病 (CD) 是一种免疫媒介疾病,在遗传敏感的个体中由质引发.
- 疾病呈现出各种胃肠道和非胃肠道症状.
- 肠道微生物群的改变可能会影响CD的表现和临床结果.
研究的目的:
- 调查肠道微生物群概况与儿科患者的临床特征之间的相关性.
主要方法:
- 纳入了38名儿科CD患者 (平均年龄10.24岁).
- 使用了以前研究中的便微生物群相对丰度数据.
- 收集了临床数据,人口统计数据和人类白细胞抗原 (HLA) -DQ2 / DQ8基因定型.
主要成果:
- 在肠道微生物群和GI和非GI症状之间发现了显著的相关性.
- 特定的细菌与腹 (Enterobacteriaceae,Streptococcus),吐 (Staphylococcus),体重减轻 (Firmicutes,Actinobacteria) 和疲劳 (Verrucomicrobia) 有关.
- HLA-DQ2基因型与特定的细菌群体 (贝塔蛋白细菌,普雷沃特拉,维龙内拉) 相关联.
结论:
- 不同的肠道微生物群模式受到症状表现和儿科CD中的HLA-DQ基因型的影响.
- 这些发现凸显了对肠道微生物群调节在疾病管理中的治疗潜力的进一步研究的需要.
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