大脑细胞外空间:从被忽视的维度到新的神经科学范式的催化剂
Hongbin Han1,2,3, Hui Dai1,3, Leonor Serrano Lopes4,5
1Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Cyborg and bionic systems (Washington, D.C.)
|March 6, 2026
概括
治疗大脑疾病的疗法经常失败,原因是忽视了大脑.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 中枢神经系统 (CNS) 疗法的低转化成功是临床实践中的一个重大挑战.
- 在临床前研究,临床实践和监管框架中,脑细胞外空间 (ECS) 历史上一直被忽视,导致治疗失败.
- 最近成像和定量测量方法的进步凸显了ECS的重要性.
研究的目的:
- 调查中枢神经系统药物和治疗设备的低转化成功的决定因素.
- 审查阻碍ECS研究的历史和技术障碍.
- 强调将ECS整合到治疗大脑疾病的治疗策略中的变革潜力.
主要方法:
- 关于ECS研究中的历史和技术瓶的文献综述.
- 分析证据,将ECS疏忽与脑疾病治疗的低翻译成功联系起来.
- 关于将ECS纳入神经科学研究,临床评估和医学教育的建议.
主要成果:
- 忽视大脑细胞外空间 (ECS) 是许多大脑疾病疗法无效的一个关键因素.
- 历史和技术的局限性导致低估了ECS在药物开发和治疗中的作用.
- 将ECS整合到当前的神经科学框架中,为开发精确疗法提供了一个有前途的途径.
结论:
- 将ECS纳入神经科学研究,临床监管评估和医学教育对于推进大脑疾病治疗至关重要.
- 为了实现精密治疗,需要一个包括ECS在内的全面范式.
- 解决ECS历史上的忽视问题可以显著提高神经和精神疾病治疗的转化成功率.
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