人类免疫缺陷病毒和上胃肠道出血患者的种族差异:全国性研究 (2016-2021)
Diviya Bharathi Ravikumar1, Naveen Yellappa2, Barath Prashanth Sivasubramanian3
1University of Alabama at Birmingham, Alabama, USA.
Le infezioni in medicina
|March 6, 2026
概括
患有艾滋病毒和上胃肠道出血的非裔美国人面临的死亡率高于白人美国人. 需要有针对性的医疗保健策略来解决这一群体的差异.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 胃肠病学 胃肠病学
背景情况:
- 在美国,有超过120万人感染艾滋病毒 (PLWH).
- 与美国白人 (AW) 相比,非洲裔美国人 (AA) 的艾滋病毒死亡率明显高.
- 上部胃肠道出血 (UGIB) 是PLWH不常见但严重的并发症,数据有限.
研究的目的:
- 分析非裔美国人和美国白人之间经历UGIB的PLWH死亡率差异.
- 为了确定与这种患者群体死亡率增加相关的风险因素.
主要方法:
- 国家住院患者样本数据库 (2016-2021) 的回顾性横截面分析.
- 使用ICD-10代码识别PLWH (年龄≥18) 与UGIB.
- 多变量回归分析以评估死亡风险,调整社会人口统计学因素和并发症.
主要成果:
- 在需要ICU护理的6,923名UGIBPLWH中,AA (37.1%) 的死亡率高于AW (29.9%).
- 与AW相比,AA显示了较高的整体死亡风险 (p<0.05).
- 伴随性疾病如水出血,恶性瘤和败血症在AA队列中显著增加了死亡风险.
结论:
- 与美国白人相比,患有UGIB的非裔美国人死亡风险更高.
- 这些发现强调了对AA PLWH经历UGIB的公平医疗保健和有针对性的干预措施的需要.
- 解决医疗保健障碍对于减少死亡率差异至关重要.
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