在精神分裂症患者中,从每月一次向更长时间间隔的注射巴利皮里棕酸转换的临床实践建议:中国的一项修改后的Delphi研究
Hong Ma1, Jun Cai2, Fujun Jia3
1Department of Psychiatry, Peking University Institute of Mental Health (Sixth Hospital), NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People's Republic of China.
Neuropsychiatric disease and treatment
|March 6, 2026
概括
这项研究在中国建立了专家共识,即使用更长时间的长效注射抗精神病药物 (LAI) 治疗精神分裂症. 它提供了关于患者选择和切换策略的指导,以改善长期疾病管理.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 药理学 药理学是指药理学的学科.
- 临床实践指南 临床实践指南
背景情况:
- 精神分裂症对社会经济构成重大负担.
- 与口服抗精神病药物相比,长效注射抗精神病药物 (LAI) 改善了坚持并减少了复发.
- 切换到更长间隔的LAI为管理精神分裂症结果提供了进一步的好处.
研究的目的:
- 在精神分裂症治疗中,就将患者转换为更长间隔的LAI的策略达成临床共识.
- 为在中国使用较长间隔的LAI制定基于证据的指导方针.
主要方法:
- 一个经过修改的Delphi研究,涉及一个指导委员会和13名小组成员.
- 问卷设计以文献审查和专家采访为指导.
- 采用九分利克特级别进行两轮一对一采访,然后进行定性分析和最后一次专家会议.
主要成果:
- 在五个关键领域的33个陈述达成共识:临床必要性,患者选择,切换策略,长期管理和治疗意愿.
- 35个声明取得了强烈的共识,其中一个中度和一个接近共识.
- 课内相关系数从0.674提高到0.751,表明了更强大的协议.
结论:
- 这项研究提出了中国首个专家共识,关于使用更长间隔的LAI治疗精神分裂症.
- 该共识提供了关于患者选择,切换策略和长期疾病管理的指导.
- 这些发现旨在促进更长间隔的LAI的标准化临床应用,改善患者的治疗结果.
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